Programme Imprimer

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Thursday, October 21st

14:15-17:00 Granulocyte Working Party
  Chair: J. Bux (Germany)

• Results of the GIW QAE 2010
G. Lucas (UK)

• Results of the GIW QAE 2009
A. Reil (Germany)

• HNA-1a antibody standard
P. Metcalfe (UK)

• HNA-1a antibody standard
G. Lucas (UK)

• New Working Party Regulations Steering Committee Discussion and Election

• Pathogenesis of TRALI due to HLA class II antibodies
Sachs (Germany)

• Use of cell lines expressing HNA antigens for granulocyte antibody detection
F. Hirayama (Japan)

17:15 Opening of the symposium
  C. Kaplan (France)
17:30-18:00 Keynote address


17:30-18:00 Honorig the Memory of Dr Diana Beardsley: Her View of Evans Syndrome;
Platelet Transport and Adhesion/Aggregation in Flowing Blood: Blood-Borne vs Vascular Tissue Factor
  E. Grabowski (USA)
18:15 Welcome cocktail - Beaune Congress Centre
   

Friday, October 22nd

8:15-10:15

Platelet biology, role in disease

  Chairs: F. Dignat-George (France), D. Varon (Israël)
8:15-8:45

Role of platelet-derived microparticles in tumor biology and tissue regeneration


D. Varon (Israël)
8:45-9:15

Endothelial-derived miicroparticules: biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis


F. Dignat-George (France)
9:15-9:45

Prolonged functions of platelets regulate thrombosis and inflammation


A. Weyrich (USA)
9:45-10:15

Platelet-Granulocyte interactions


B. Kehrel (Germany)


10:15-10:45 Coffee Break / Posters and exhibition visit
   
10:45-12:45

Immune response


Chairs: O. Garraud, H. Watier (France)
10:45-11:15

Platelets toll-like receptor expression: the link between "danger" ligands and inflammation

  O. Garraud (France)
11:15-11:45

Clinical approaches for studying Fc receptors: lessons from rituximab pharmacogenetics

  H. Watier (France)
11:45-12:15

Regulated glycosylation patterns of IgG during alloimmune responses against human platelet antigens

  R. Kapur (Netherlands)
12:15-12:45

Regulatory T cell compartment in ITP patients on treatment with thrombopoietic agents

  K. Yazdanbakhsh (USA)


12:45-13:45 Lunch / Satellite Symposium GTI Diagnostics
Platelet Antibody Screening and Identification


12:45-13:15

Application of platelet antibody test results in the diagnosis of immune platelet disorders and the utility of platelet antigen bead arrays


B. Curtis, USA


13:15-13:35

LIFECODESTM PAK LxTM A multiparameter assay for detection of antibodies to Human Platelet Antigens


G.P. Visentin, USA


14:15-15:45

Drug-induced thrombocytopenia    


Chair: S. Santoso (Germany)
14:15-14:45

Drug-induced immune thrombocytopenia: Pathogenesis and diagnosis


R. Aster (USA)
14:45-15:45

Fetal/maternal interface

  Chairs: M. Paidas (USA), S. Panzer (Austria)
14:45-15:15

Placental immunology and maternal alloimmune responses

  B. Kumpel (UK)
15:15-15:45

Materno-fetal interface: lessons from physiology towards therapeutics


S. André (France)


15:45-16:15 Coffee break - Poster and exhibition visit


16:15-17:45

Neonatal alloimmune thrombocytopenia 1


Chairs: A. Husebekk (Norway), J. Semple (Canada)
16:15-16:45

T-cell Responses Associated with Neonatal Alloimmune Thrombocytopenia


T.B. Stuge (Norway)
16:45-17:15

Fetomaternal Alloimmune Thrombocytopenia (FMAIT) and immunomodulation


S. Urbaniak (UK)
17:15-17:45

Pathogenesis of Fetal and Neonatal Immune Thrombocytopenia: Lessons from animal models


H. Ni (Canada)
17:45-19:00

 Oral abstracts: Alloimmune thrombocytopenia


Chairs: V. Kiefel, H. Kroll (Germany)
17:45-17:55

OA01 - T-cell responses associated with neonatal alloimmune thrombocytopenia: the role of the allogeneic Leu33 residue in HPA-1a


M.T. Ahlen (Norway)
17:55-18:05

OA02 - HLA-DRB3*0101 exhibits a dose-dependent impact on maternal HPA 1a-antibody levels in HPA 1a-immunized women


T.L. Titze (Norway)
18:05-18:15

OA03 -Effect of HPA-1a peptides on in vivo anti-HPA-1a responses


D. Jackson (UK)
18:15-18:25

OA04 - Maternal antibodies to fetal platelet GPIbα cause more frequent miscarriage than anti-β3 integrin antibodies in animal models of fetal and neonatal immune thrombocytopenia (FNIT): A possible explanation for low reported incidence of anti-GPIbα mediated FNIT


H. Ni (Canada)
18:25-18:35

OA05 - A high affinity monoclonal anti-HPA-1a antibody derived from memory B cells of a woman alloimmunized in connection with pregnancy


M. Eksteen (Norway)
18:35-18:45

OA06 - Prophylactic administration of anti-β3 antibodies induced antibody mediated immune suppression (AMIS) and prevented severe clinical complications in a murine model of fetal and neonatal alloimmune thrombocytopenia (FNAIT)


H. Tiller (Norway)
18:45-18:55

OA07 - In vivo assesment of an asn-297-linked n-glycan modified HPA-1a-specific monoclonal antibody for the treatment of neonatal alloimmune thrombocytopenia


T. Bakchoul (Germany)


19:15-21:00 Wine and local specialities tasting - Beaune Congress Centre

Saturday, October 23rd

8:15-10:15

Genetic disorders and platelet polymorphisms

  Chairs: C. L. Balduini (Italy), T. Lecompte (France)
8:15-8:45

MYH9-related disorders: from gene to therapy

  C. L. Balduini (Italy)
8:45-9:15

Platelet glycoprotein VI deficiencies

  M. Jandrot-Perrus (France)
9:15-9:45

GT, lessons regarding structure-function relationships

  N. Rosenberg (Israel)
9:45-10:15

αΙΙbβΙΙΙ polymorphisms and structure modelling


V. Jallu (France)


10:15-10:45 Coffee Break / Posters and exhibition visit
   
10:45-12:15

Platelet transfusions: future challenges

  Chairs: Y. Gruel (France)
10:45-11:15

In vitro platelet formation

  D. Baruch (France)
11:15-12:15

Autoimmune thrombocytopenia

  Chairs: M. de Haas (Netherlands), M. Uhrynowska (Poland)
11:15-11:45

An update on the immunopathogenesis of ITP

  J. Semple (Canada)
11:45-12:15

Novel Treatments of ITP

  J. Bussell (USA)
12:15-12:30

Alan Waters' Award

  Chairs: C. Kaplan (France), J. Chapman (Netherlands)
12:15-12:30

OA08 - Development of novel reagents to study the presentation of HPA-1a peptide in the context of HLA-DRA/DRB3*0101 by maternal antigen presenting cells

  E. Bouwmans (UK)


12:30-13:45 Lunch / Satellite symposium IMMUCOR


12:30-12:45

Immune thrombocytopenia: current investigations in platelet immunology

  G. Bertrand (France)


12:45-13:00

Experience with Immucor automated Capture technology for Platelet Immunohematology

  D. Donatella (Italy)


13:00-13:15

Combination of Capture P and BioArray technology in the establishment of an HPA1 negative donor file

  L. Barea (Spain)


13:15-13:30

Experience with implementing platelet crossmatching and its effect on patient outcomes

  C. Lüdiecke (Germany)


13:30-13:45

Roundtable discussion

  C. Kaplan and with the joint participation of S. Santoso, C. Picard and S. Urbaniak


14:15-15:15

Immunoglobulins

  Chairs: J. Bussel (USA), A. Lazarus (Canada)
14:15-14:45

Mechanisms of action of IVIg in ITP

  A. Lazarus (Canada)
14:45-15:15

Mechanisms of action of IVIg in autoimmune and inflammatory diseases: an update

  S.V. Kaveri (France)
15:15-15:45

 Oral abstracts: Autoimmunity, Platelet miscellaneous

  Chairs: L. Golovkina (Russian Federation), A. Wikman (Sweden)
15:15-15:25

OA09 - Endoglycosidase f treatment prevents autoantibody-mediated clearance of human platelet in an in vivo model of immune thrombocytopenia

  T. Bakchoul (Germany)
15:25-15:35

OA10 - Efficacy of steroid therapy in ameliorating ITP mediated by anti-platelet GPIIbIIIa versus GPIbα antibodies

  H. Ni (Canada)
15:35-15:45 OA11 - Plasma fibronectin supports hemostasis in mice lacking fibrinogen and/or von Willebrand factor
  H. Ni (Canada)


15:45-16:15

Coffee Break / Exhibition visit and poster session



17:00-17:45

 Heparin-induced thrombocytopenia

  Chairs: P. Nguyen (France), M. Tomicic (Croatia)
17:00-17:30

Heparin-induced thrombocytopenia: Is there a genetic predisposition?

  Y. Gruel (France)
17:30-17:45

Class I HLA antibodies are the major cause of indeterminate serotonin releae assay (SRA) test results in heparin-induced thrombocytopenia (HIT)

  B. Curtis (USA)
17:45-18:05

Oral abstracts: Platelet immunology laboratory testing

  Chairs: E. Taaning (Denmark), E. Muniz-Diaz (Spain)
17:45-17:55

OA12 - Platelet genotyping of low frequency antigens: a one year experience

  T. Beranger (France)
17:55-18:05

OA13 - Detection of low avidity HPA-1a antibodies in neonatal alloimmune thrombocytopenia (NAIT) using surface plasmon resonance

  J. Peterson (USA)

19:00-23:00 Beaune Hospices and official dinner

Sunday, October 24th

8:15-10:15

Granulocyte immunobiology


Chairs: Y.L. Fung (Australia), J. Bux (Germany)
8:15-8:40

Developments in the detection of HNA and HLA antibodies

  Y.L. Fung (Australia)
8:40-9:05

Human Neutrophil Alloantigens - an update

  J. Bux (Germany)
9:05-9:30

The role of HLA class II antibodies in TRALI

  P. Kopko (USA)
9:30-9:55

Role of human neutrophil antigen-2a in inflammation

  S. Santoso (Germany)
9:55-10:15

Leukocyte antibodies in TRALI

  H. Okazaki (Japan)


10:15-10:45 Coffee Break / Posters and exhibition visit
   
10:45-12:30

Neonatal alloimmune thrombocytopenia 2


Chairs: H. Ni (Canada), N. Winer (France)
10:45-11:15

Animal Model in Platelet Immunology

  T. Bakchoul (Germany)
11:15-11:45

Non-invasive fetal blood typing for platelet and red cell antigens

  P.G. Scheffer (Netherlands)
11:45-12:15

Round Table Discussion on Neonatal Alloimmune Thrombocytopenia, management, screening programme?

  Moderators: B. Skogen (Norway), M. Paidas (USA)
12:30 End of the meeting