Programme

Thursday, October 21st

14:15-17:00	Granulocyte Working Party
	Chair: J. Bux (Germany)
	• Results of the GIW QAE 2010 G. Lucas (UK) • Results of the GIW QAE 2009 A. Reil (Germany) • HNA-1a antibody standard P. Metcalfe (UK) • HNA-1a antibody standard G. Lucas (UK) • New Working Party Regulations Steering Committee Discussion and Election • Pathogenesis of TRALI due to HLA class II antibodies Sachs (Germany) • Use of cell lines expressing HNA antigens for granulocyte antibody detection F. Hirayama (Japan)
17:15	Opening of the symposium
	C. Kaplan (France)
17:30-18:00	Keynote address

17:30-18:00	Honorig the Memory of Dr Diana Beardsley: Her View of Evans Syndrome; Platelet Transport and Adhesion/Aggregation in Flowing Blood: Blood-Borne vs Vascular Tissue Factor
	E. Grabowski (USA)
18:15	Welcome cocktail - Beaune Congress Centre

Friday, October 22nd

8:15-10:15	Platelet biology, role in disease
	Chairs: F. Dignat-George (France), D. Varon (Israël)
8:15-8:45	Role of platelet-derived microparticles in tumor biology and tissue regeneration
	D. Varon (Israël)
8:45-9:15	Endothelial-derived miicroparticules: biological conveyors at the crossroad of inflammation, thrombosis and angiogenesis
	F. Dignat-George (France)
9:15-9:45	Prolonged functions of platelets regulate thrombosis and inflammation
	A. Weyrich (USA)
9:45-10:15	Platelet-Granulocyte interactions
	B. Kehrel (Germany)

10:15-10:45	Coffee Break / Posters and exhibition visit

10:45-12:45	Immune response
	Chairs: O. Garraud, H. Watier (France)
10:45-11:15	Platelets toll-like receptor expression: the link between "danger" ligands and inflammation
	O. Garraud (France)
11:15-11:45	Clinical approaches for studying Fc receptors: lessons from rituximab pharmacogenetics
	H. Watier (France)
11:45-12:15	Regulated glycosylation patterns of IgG during alloimmune responses against human platelet antigens
	R. Kapur (Netherlands)
12:15-12:45	Regulatory T cell compartment in ITP patients on treatment with thrombopoietic agents
	K. Yazdanbakhsh (USA)

12:45-13:45	Lunch / Satellite Symposium Platelet Antibody Screening and Identification

12:45-13:15	Application of platelet antibody test results in the diagnosis of immune platelet disorders and the utility of platelet antigen bead arrays
	B. Curtis, USA

13:15-13:35	LIFECODESTM PAK LxTM A multiparameter assay for detection of antibodies to Human Platelet Antigens
	G.P. Visentin, USA

14:15-15:45	Drug-induced thrombocytopenia
	Chair: S. Santoso (Germany)
14:15-14:45	Drug-induced immune thrombocytopenia: Pathogenesis and diagnosis
	R. Aster (USA)
14:45-15:45	Fetal/maternal interface
	Chairs: M. Paidas (USA), S. Panzer (Austria)
14:45-15:15	Placental immunology and maternal alloimmune responses
	B. Kumpel (UK)
15:15-15:45	Materno-fetal interface: lessons from physiology towards therapeutics
	S. André (France)

15:45-16:15	Coffee break - Poster and exhibition visit

16:15-17:45	Neonatal alloimmune thrombocytopenia 1
	Chairs: A. Husebekk (Norway), J. Semple (Canada)
16:15-16:45	T-cell Responses Associated with Neonatal Alloimmune Thrombocytopenia
	T.B. Stuge (Norway)
16:45-17:15	Fetomaternal Alloimmune Thrombocytopenia (FMAIT) and immunomodulation
	S. Urbaniak (UK)
17:15-17:45	Pathogenesis of Fetal and Neonatal Immune Thrombocytopenia: Lessons from animal models
	H. Ni (Canada)
17:45-19:00	Oral abstracts: Alloimmune thrombocytopenia
	Chairs: V. Kiefel, H. Kroll (Germany)
17:45-17:55	OA01 - T-cell responses associated with neonatal alloimmune thrombocytopenia: the role of the allogeneic Leu33 residue in HPA-1a
	M.T. Ahlen (Norway)
17:55-18:05	OA02 - HLA-DRB3*0101 exhibits a dose-dependent impact on maternal HPA 1a-antibody levels in HPA 1a-immunized women
	T.L. Titze (Norway)
18:05-18:15	OA03 -Effect of HPA-1a peptides on in vivo anti-HPA-1a responses
	D. Jackson (UK)
18:15-18:25	OA04 - Maternal antibodies to fetal platelet GPIbα cause more frequent miscarriage than anti-β3 integrin antibodies in animal models of fetal and neonatal immune thrombocytopenia (FNIT): A possible explanation for low reported incidence of anti-GPIbα mediated FNIT
	H. Ni (Canada)
18:25-18:35	OA05 - A high affinity monoclonal anti-HPA-1a antibody derived from memory B cells of a woman alloimmunized in connection with pregnancy
	M. Eksteen (Norway)
18:35-18:45	OA06 - Prophylactic administration of anti-β3 antibodies induced antibody mediated immune suppression (AMIS) and prevented severe clinical complications in a murine model of fetal and neonatal alloimmune thrombocytopenia (FNAIT)
	H. Tiller (Norway)
18:45-18:55	OA07 - In vivo assesment of an asn-297-linked n-glycan modified HPA-1a-specific monoclonal antibody for the treatment of neonatal alloimmune thrombocytopenia
	T. Bakchoul (Germany)

19:15-21:00	Wine and local specialities tasting - Beaune Congress Centre

Saturday, October 23rd

8:15-10:15	*Genetic disorders and platelet polymorphisms*
	Chairs: C. L. Balduini (Italy), T. Lecompte (France)
8:15-8:45	MYH9-related disorders: from gene to therapy
	C. L. Balduini (Italy)
8:45-9:15	Platelet glycoprotein VI deficiencies
	M. Jandrot-Perrus (France)
9:15-9:45	GT, lessons regarding structure-function relationships
	N. Rosenberg (Israel)
9:45-10:15	αΙΙbβΙΙΙ polymorphisms and structure modelling
	V. Jallu (France)

10:15-10:45	Coffee Break / Posters and exhibition visit

10:45-12:15	Platelet transfusions: future challenges
	Chairs: Y. Gruel (France)
10:45-11:15	In vitro platelet formation
	D. Baruch (France)
11:15-12:15	Autoimmune thrombocytopenia
	Chairs: M. de Haas (Netherlands), M. Uhrynowska (Poland)
11:15-11:45	An update on the immunopathogenesis of ITP
	J. Semple (Canada)
11:45-12:15	Novel Treatments of ITP
	J. Bussell (USA)
12:15-12:30	Alan Waters' Award
	Chairs: C. Kaplan (France), J. Chapman (Netherlands)
12:15-12:30	OA08 - Development of novel reagents to study the presentation of HPA-1a peptide in the context of HLA-DRA/DRB3*0101 by maternal antigen presenting cells
	E. Bouwmans (UK)

12:30-13:45	Lunch / Satellite symposium

12:30-12:45	Immune thrombocytopenia: current investigations in platelet immunology
	G. Bertrand (France)

12:45-13:00	Experience with Immucor automated Capture technology for Platelet Immunohematology
	D. Donatella (Italy)

13:00-13:15	Combination of Capture P and BioArray technology in the establishment of an HPA1 negative donor file
	L. Barea (Spain)

13:15-13:30	Experience with implementing platelet crossmatching and its effect on patient outcomes
	C. Lüdiecke (Germany)

13:30-13:45	Roundtable discussion
	C. Kaplan and with the joint participation of S. Santoso, C. Picard and S. Urbaniak

14:15-15:15	Immunoglobulins
	Chairs: J. Bussel (USA), A. Lazarus (Canada)
14:15-14:45	Mechanisms of action of IVIg in ITP
	A. Lazarus (Canada)
14:45-15:15	Mechanisms of action of IVIg in autoimmune and inflammatory diseases: an update
	S.V. Kaveri (France)
15:15-15:45	Oral abstracts: Autoimmunity, Platelet miscellaneous
	Chairs: L. Golovkina (Russian Federation), A. Wikman (Sweden)
15:15-15:25	OA09 - Endoglycosidase f treatment prevents autoantibody-mediated clearance of human platelet in an in vivo model of immune thrombocytopenia
	T. Bakchoul (Germany)
15:25-15:35	OA10 - Efficacy of steroid therapy in ameliorating ITP mediated by anti-platelet GPIIbIIIa versus GPIbα antibodies
	H. Ni (Canada)
15:35-15:45	OA11 - Plasma fibronectin supports hemostasis in mice lacking fibrinogen and/or von Willebrand factor
	H. Ni (Canada)

15:45-16:15	Coffee Break / Exhibition visit and poster session

17:00-17:45	Heparin-induced thrombocytopenia
	Chairs: P. Nguyen (France), M. Tomicic (Croatia)
17:00-17:30	Heparin-induced thrombocytopenia: Is there a genetic predisposition?
	Y. Gruel (France)
17:30-17:45	Class I HLA antibodies are the major cause of indeterminate serotonin releae assay (SRA) test results in heparin-induced thrombocytopenia (HIT)
	B. Curtis (USA)
17:45-18:05	Oral abstracts: Platelet immunology laboratory testing
	Chairs: E. Taaning (Denmark), E. Muniz-Diaz (Spain)
17:45-17:55	OA12 - Platelet genotyping of low frequency antigens: a one year experience
	T. Beranger (France)
17:55-18:05	OA13 - Detection of low avidity HPA-1a antibodies in neonatal alloimmune thrombocytopenia (NAIT) using surface plasmon resonance
	J. Peterson (USA)

19:00-23:00	Beaune Hospices and official dinner

Sunday, October 24th

8:15-10:15	Granulocyte immunobiology
	Chairs: Y.L. Fung (Australia), J. Bux (Germany)
8:15-8:40	Developments in the detection of HNA and HLA antibodies
	Y.L. Fung (Australia)
8:40-9:05	Human Neutrophil Alloantigens - an update
	J. Bux (Germany)
9:05-9:30	The role of HLA class II antibodies in TRALI
	P. Kopko (USA)
9:30-9:55	Role of human neutrophil antigen-2a in inflammation
	S. Santoso (Germany)
9:55-10:15	Leukocyte antibodies in TRALI
	H. Okazaki (Japan)

10:15-10:45	Coffee Break / Posters and exhibition visit

10:45-12:30	Neonatal alloimmune thrombocytopenia 2
	Chairs: H. Ni (Canada), N. Winer (France)
10:45-11:15	Animal Model in Platelet Immunology
	T. Bakchoul (Germany)
11:15-11:45	Non-invasive fetal blood typing for platelet and red cell antigens
	P.G. Scheffer (Netherlands)
11:45-12:15	Round Table Discussion on Neonatal Alloimmune Thrombocytopenia, management, screening programme?
	Moderators: B. Skogen (Norway), M. Paidas (USA)
12:30	End of the meeting